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茜草科植物钩藤(Uncaria rhynchoph-ylla(MiqJackson)具有降压作用早经实验室证实。钩藤降压片经天津市药品检验药物研究所鉴定已收载于1977年版中华人民共和国药典。目前国内有广西东兰等数家制药厂生产钩藤总碱(下称总碱)片供临床应用。关于钩藤总碱药理作用的实验室研究及临床观察陆续有报道。鉴于钩藤碱(Rhynchophlline)是钩藤总碱的主要降压成分,而有关钩藤碱的血流动力学尚未研究报告。本文以电磁流量法观察钩藤碱对麻醉犬和猫血流动力学的影响。方法实验动物为9.8±0.5((?)±SD)kg 的犬和3.0±0.3((?)±SD)kg 麻醉的猫,雌雄兼有。静
The Uncaria rhynchoph-ylla (MiqJackson) has a hypotensive effect in the promenorrhea laboratories. Houteng Jiangya Tablets have been identified in the Pharmacopoeia of the People’s Republic of China in 1977. There are several pharmaceutical factories in Guangxi Donglan, etc., which produce the total alkaloids of Uncaria Rhizome (hereinafter referred to as total alkali) for clinical application.The laboratory research and clinical observation on the pharmacological effects of Rhynchophylla total alkaloids have been reported one after another. It is the main antihypertensive component of Rhizoma Rhynchophylla, and the hemodynamics of Rhynchophylline has not been reported yet.The effect of rhynchophylline on the hemodynamics of anesthetized dogs and cats was studied by electromagnetic flow method.Methods The experimental animals were 9.8 ± 0.5 ((?) ± SD) kg of dogs and 3.0 ± 0.3 ((?) ± SD) kg of anesthetized cats, both male and female.