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自身免疫性胰腺炎(autoimmune pancreatitis,AIP)是一种特殊类型的慢性胰腺炎,至今未发现明确的发病机制。1961年,Sarles等~([1])首先报道了1例伴有高γ球蛋白血症的慢性硬化性胰腺炎,表明该病可能与自身免疫因素有关,该例胰腺炎表现为胰腺广泛肿大伴胰管不规则狭窄,且间接免疫荧光法抗核抗体(antinuclear antibody,ANA)阳性。2001年,AIP已被作为慢性胰腺炎的一种独立分型而存在。AIP分为两型~([2]),1型为淋巴浆细胞硬化性胰腺炎(lymphoglasmacytic sclerosing pancreatitis,LPSP),特点是受累组织器
Autoimmune pancreatitis (AIP) is a special type of chronic pancreatitis, to date, no clear pathogenesis has been found. In 1961, Sarles et al. ([1]) first reported a case of chronic sclerosing pancreatitis accompanied by high-gammaglobulinemia, indicating that the disease may be related to autoimmune factors, the case of pancreatitis showed extensive pancreas Large with pancreatic duct irregular stenosis, and indirect immunofluorescence antinuclear antibody (antinuclear antibody, ANA) positive. In 2001, AIP was present as an independent type of chronic pancreatitis. AIP is divided into two types ~ ([2]), type 1 lymphoplasma sclerosing pancreatitis (lymphoglasmacytic pancreatitis, LPSP), characterized by involvement of the organizer