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异名 Rangasil、Rengasil、C 21524 SU 化学名 2-[3-氯-4-(3-吡咯啉-1-基)苯基]丙酸药效分类解热镇痛抗炎药开发单位(瑞士)Ciba Geigy 上市厂商(法)Ciba-Geigy 1983年5月文献 Fed Proc 1973,32:803 AbsClin Pharmacol Ther 1974,16(1):69 药理本品为极强的非甾体抗炎药。动物实验中,在镇痛、解热和抗炎方面均有显著活性。它抑制前列腺素合成酶,对白细胞的趋化性具有抑制作用。大鼠脚爪水肿试验、棉球肉芽肿试验和佐剂关节炎等药理研究,均显示本品的抗炎
Synonyms Rangasil, Rengasil, C 21524 SU Chemical name 2- [3-chloro-4- (3-pyrrolin-1-yl) phenyl] propionic acid Pharmacodynamic class Antipyretic and analgesic antiinflammatory drug Development Unit (Switzerland) Ciba Geigy Listed Company Ciba-Geigy May 1983 Document Fed Proc 1973, 32: 803 AbsClin Pharmacol Ther 1974, 16 (1): 69 Pharmacology This product is a potent non-steroidal anti-inflammatory drug. Animal experiments, in the analgesic, antipyretic and anti-inflammatory aspects have significant activity. It inhibits prostaglandin synthase and has an inhibitory effect on leukocyte chemotaxis. Rat paw edema test, cotton ball granuloma test and adjuvant arthritis and other pharmacological studies have shown that the anti-inflammatory products