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钙拮抗剂(Calcium-antagonists)原先是指钙通道阻滞剂(Calcium-channel blockers)。近年来有人从广义角度把钙调素(Calmodulin)拮抗剂列入这类药物。本文钙拮抗剂即为该二者的总称。七十年代初,这类钙抗剂因硝苯吡啶(Nifedipine)、硫氮卓酮(diltiazem)的出现而引起人嘱目,相应地出现了治疗作用方面的进展。它除对心绞痛、心律失常、高血压等有较好疗效外,近年来也用于抗心肌缺血的治疗和试与抗癌药物并用等方面。关于在抗肿瘤方面的作用国内尚未见报道,现将近几年来这类药物在抗肿瘤方面的作用综述如下:
Calcium-antagonists were originally Calcium-channel blockers. In recent years, some people from the broad perspective of the calmodulin (Calmodulin) antagonist included in these drugs. This article is the general term for both calcium antagonists. In the early seventies, such calcium antagonists aroused people’s attention due to the appearance of nifedipine and diltiazem, and correspondingly, there has been a progress in the therapeutic effect. In addition to its angina, arrhythmia, hypertension and other better curative effect, but also in recent years for the treatment of anti-myocardial ischemia and test and anticancer drugs and so on. On the role of anti-tumor has not been reported in the country, now in recent years the role of such drugs in the anti-tumor are summarized as follows: