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目的探讨囊胚扩张时间对玻璃化囊胚冻融周期临床结局的预测价值。方法回顾性分析2012年1月至2012年12月在广西壮族自治区妇幼保健院生殖医学中心接受冻融单囊胚移植的年龄小于38岁的患者资料。根据其复苏后囊胚的扩张时间分为三组:扩张时间≤1h(A组),扩张时间>1h,但<2h(B组),扩张时间≥2h(C组)。比较三组的临床妊娠结局。结果 A、B和C三组间的临床妊娠率差异有统计学差异(P<0.05)。A组的临床妊娠率显著高于B组和C组(分别为:69.70%vs 52.6%vs 29.21%,P<0.05),C组临床妊娠率显著低于B组(P<0.05)。而各组间的流产率差异无统计学差异(分别为10.29%vs 12.50%vs 19.23%,P>0.05)。结论囊胚扩张时间越短,其发育潜能越高,妊娠结局越好,对囊胚玻璃化冻融周期的妊娠结局有重要的预测价值。
Objective To investigate the predictive value of blastocyst expansion time in the clinical outcome of vitrified blastocyst in the freeze-thaw cycles. Methods The data of patients under 38 years of age who underwent cryo-thalamic single blastocyst transplantation in the Reproductive Medicine Center of MCH Hospital of Guangxi Zhuang Autonomous Region from January 2012 to December 2012 were retrospectively analyzed. According to their post-revival blastocyst expansion time is divided into three groups: expansion time ≤ 1h (A group), expansion time> 1h, but <2h (B group), expansion time ≥ 2h (C group). The clinical pregnancy outcomes of the three groups were compared. Results There was a significant difference in clinical pregnancy rates between A, B and C groups (P <0.05). The clinical pregnancy rate in group A was significantly higher than that in group B and C (69.70% vs 52.6% vs 29.21%, respectively; P <0.05). The clinical pregnancy rate in group C was significantly lower than that in group B (P <0.05). There was no significant difference in abortion rates among the groups (10.29% vs 12.50% vs 19.23%, respectively; P> 0.05). Conclusion The shorter the time of blastocyst expansion, the higher its developmental potential and the better the outcome of pregnancy are. It has important predictive value for the pregnancy outcome of the vitrification and thawing cycles of blastocysts.