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目的探讨四联疗法对幽门螺杆菌(Hp)阳性胃溃疡患者胃功能的影响。方法选取郸城县人民医院收治的Hp阳性胃溃疡患者92例作为研究对象,采用数字随机对照表将其分为对照组和观察组,对照组予以三联疗法(克拉霉素+奥美拉唑+阿莫西林),观察组予以四联疗法(埃索美拉唑+瑞巴派特+阿莫西林+克拉霉素),测定治疗前后血清胃蛋酶原亚群(PGⅠ、PGⅡ)含量,评估治疗前后腹痛改善情况,记录两组患者溃疡愈合率和Hp转阴率。结果观察组Hp转阴率为95.65%,高于对照组的92.61%,差异有统计学意义(P<0.05);观察组治疗后1周、4周VAS评分分别为(1.38±1.53)分、(0.41±0.29)分,均低于对照组,差异有统计学意义(P<0.05);观察组治疗后PGⅠ、PGⅡ含量分别为(132.64±23.61)μg/L、(19.67±4.29)μg/L,均低于对照组,差异有统计学意义(P<0.05)。结论四联疗法可提高Hp阳性胃溃疡患者Hp转阴率,改善胃黏膜分泌功能。
Objective To investigate the effect of quadruple therapy on gastric function in patients with Helicobacter pylori (Hp) -positive gastric ulcer. Methods Forty-two Hp-positive gastric ulcer patients admitted to Dancheng People’s Hospital were enrolled in this study. The patients were divided into control group and observation group by digital randomized control table. The control group was treated with triple therapy (clarithromycin plus omeprazole + Amoxicillin). The observation group was treated with quadruple therapy (esomeprazole + rebamipide + amoxicillin + clarithromycin), and the levels of serum PG Ⅰ and PGⅡ were measured before and after treatment. Before and after treatment of abdominal pain to improve the situation, record the two groups of patients with ulcer healing rate and Hp conversion rate. Results The negative rate of Hp in the observation group was 95.65%, which was higher than that in the control group (92.61%), the difference was statistically significant (P <0.05). The VAS scores of the observation group were 1.38 ± 1.53 at 1 week and 4 weeks respectively, (0.41 ± 0.29), which were lower than those in the control group (P <0.05). The contents of PGⅠ and PGⅡ in the observation group were (132.64 ± 23.61) μg / L and (19.67 ± 4.29) μg / L, both lower than the control group, the difference was statistically significant (P <0.05). Conclusions Quadruple therapy can improve Hp negative rate and improve gastric mucosal secretory function in Hp positive gastric ulcer patients.