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目的探讨肾小球疾病与唾液酸（ＳＡ）含量的关系。方法测定１０２例肾小球疾病患儿血、尿中的唾液酸含量。结果除无症状性血尿组外，急性肾炎、肾病综合征患儿的血、尿ＳＡ均值均显著高于对照组（Ｐ＜０．０１），并发现急性肾炎、肾病综合征血ＳＡ浓度与尿蛋白呈显著正相关（Ｐ＜０．０１），而与尿素氮（ＥＵＮ），肌酐（Ｃｒ）无相关（Ｐ＞０．０５）．对急性肾炎、肾病综合征各２０例进行治疗前后比较，发现随着病情的好转，血、尿ＳＡ浓度呈明显下降趋势。结论血，尿ＳＡ浓度测定可作为肾小球疾病病情的观察指标。
Objective To investigate the relationship between glomerular disease and sialic acid (SA) content. Methods 102 cases of glomerular disease in children with blood sialic acid content. Results In addition to asymptomatic hematuria, acute nephritis, nephrotic syndrome in children with blood and urine SA were significantly higher than the control group (P <0.01), and found that acute nephritis, nephrotic syndrome serum SA concentration and urine (P <0.01), but no correlation with urea nitrogen (NUN) and creatinine (P> 0.05). Acute nephritis, nephrotic syndrome in each of 20 cases before and after treatment and found that with the condition improved, serum and urinary SA concentrations showed a significant downward trend. Conclusion Serum and urinary SA concentrations can be used as indicators of glomerular disease.