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α-氨基酸(下简称氨基酸)合成研究的历史已久,可以说随着有机化学的诞生便开始了。至六十年代,一般合成方法已使用殆尽。后在酶法和发酵法突飞猛进的鼓舞下,由于以制取光学活性体为目标的不对称合成研究而获得了发展。本文就其主要合成方法,概述如下: 一、氨基导入法 1.直接氨基化法: 历来的氨基化反应,氨类均作为亲核试剂,至六十年代末期,则出现了以氨类为亲电试剂的新氨基化合成氨基酸方法。
The research on the synthesis of α-amino acids (amino acids for short) has been a long time. It can be said that with the birth of organic chemistry, it started. By the 1960s, general synthesis methods were exhausted. Inspired by the rapid advances in enzymatic and fermentation processes, advances have been made in the asymmetric synthesis of opto-actives. In this paper, its main synthesis methods, summarized as follows: First, the amino import method 1. Direct amination method: the amination has always been, ammonia as a nucleophile, to the late sixties, then appeared to ammonia as a pro New Amino Acid Synthesis of Amino Acids.