A series of novel 3-alkylthio-4-arylideneamino-5-(2-furyl)-1, 2, 4-triazole derivatives were synthesized. Their chemical structures were confirmed with elemental analysis and spectral data. Endothelin(ET) receptor competitive binding assay showed that some compounds exhibited high selective as potent ET-1 receptor antagonist. A series of novel 3-alkylthio-4-arylideneamino-5- (2-furyl) -1,2,4-triazole derivatives were synthesized. Their chemical structures were confirmed with elemental analysis and spectral data. Endothelin (ET) receptor competitive binding assay showed that some compounds exhibited high selective as potent ET-1 receptor antagonist.