空泡毒素(VacA)是幽门螺杆菌(Hp)一个重要的毒力因子,口服纯化VacA可以对小鼠再感染产毒Hp菌株产生有效保护。然而,野生型VacA蛋白由于其致胃上皮细胞损伤作用而不能成为候选疫苗。尽管现在认为基因水平灭活毒力VacA蛋白可以成为合适的候选疫苗,但基因点突变是否可以将 Vaccinium is an important virulence factor of Helicobacter pylori (Hp). Oral administration of VacA effectively protects mice from re-infecting Hp-producing strains. However, wild-type VacA protein can not be a candidate vaccine due to its role in damaging gastric epithelial cells. Although it is now considered that gene-level inactivation of virulence VacA protein can be a suitable candidate vaccine, whether gene point mutations can be