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[目的]探讨尿微量白蛋白(MA)、免疫球蛋白G(IgG)和α1微球蛋白(α1-MG)检测在儿童过敏性紫癜(HSP)肾损伤中的诊断价值。[方法]检测89例HSP患儿尿MA、IgG和α1-MG的水平,计算其阳性率,并与尿红细胞形态检查阳性率结果进行比较。[结果]尿红细胞形态检查对HSP患儿肾损伤检出率为40.4%;尿MA、IgG和α1-MG3项联合检测和尿MA、α1-MG二项联合检测对HSP肾损伤检出率分别为62.9%和59.6%,与红细胞形态检查比较差异均有统计学意义(P值分别为0.001和0.003);尿MA、IgG和α1-MG各单项检查对HSP肾损伤检出率较尿红细胞形态检查无明显不同(P值分别为0.648、0.296和0.302)。[结论]尿MA和α1-MG联合检测对HSP肾损伤的诊断有较高的临床应用价值,而指标尿IgG对HSP肾损伤的诊断价值还需进一步研究。
[Objective] To investigate the diagnostic value of urine microalbumin (MA), immunoglobulin G (IgG) and α1-microglobulin (α1-MG) in renal injury of Henoch-Schonlein purpura (HSP) in children. [Methods] The levels of MA, IgG and α1-MG in 89 cases of HSP were detected and the positive rate was calculated. The positive rate of urinary erythrocyte morphology was also compared. [Results] The detection rate of urinary red cell morphology in children with HSP was 40.4%. The combined detection of urinary MA, IgG and α1-MG3 and urine MA, α1-MG combined detection of HSP kidney injury were respectively Were 62.9% and 59.6%, respectively, which were significantly different from that of erythrocyte morphology (P = 0.001 and 0.003, respectively) No significant difference was observed (P values were 0.648, 0.296 and 0.302, respectively). [Conclusion] The combined detection of urinary MA and α1-MG has a high clinical value in the diagnosis of HSP in renal injury. However, the diagnostic value of urinary IgG to HSP in renal injury needs to be further studied.