【摘 要】
：
Smad3 and STAT3 are intracellular molecules that transmit signals from plasma membrane receptors to the nucleus.Smad3 operates downstream of growth/differentiat
【机 构】
：
Department of Biochemistry, Graduate School of Medicine, University of Yamanashi, 1110 Shimokato, Ch
论文部分内容阅读
Smad3 and STAT3 are intracellular molecules that transmit signals from plasma membrane receptors to the nucleus.Smad3 operates downstream of growth/differentiation factors that utilize activin receptor-like kinase (ALK)-4,5,or 7,such as transforming growth factor-β (TGF-β),activin,and myostatin.STAT3 principally functions downstream of cytokines that exert their effects via gp130 and Janus family kinases,including interleukin-6 (IL-6),leukemia inhibitory factor (LIF),and oncostatin M.Accumulating evidence indicates that Smad3 and STAT3 engage in crosstalk in a highly context-dependent fashion,cooperating in some conditions while acting antagonistically each other in others.Here,we review the crosstalk between Smad3 and STAT3 in various biological contexts,including early tumorigenesis,epithelial-mesenchymal transition,fibrosis,and T cell differentiation.
其他文献
Filamin A (FLNa) is a ubiquitously expressed cytoplasmic protein,which composes of an N-terminal actin binding domain (ABD) followed by 24 lg-like repeats.FLNa
The relationship of carcinogenesis and DNA methyltransferases has attracted extensive attention in tumor research.We reported previously that inhibition of de n
洋葱（Allium cepa L.）为百合科葱属二年生草本植物，有普通洋葱、分蘖洋葱和顶球洋葱三个变种。洋葱风味独特，且有降血压、降血脂、抗动脉硬化和预防心肌梗塞的作用，现已被广泛应用
1.选地隔离玉米是异花授粉作物,极易串花。因此,安全隔离在玉米制种过程中显得特别重要。隔离的方法有多种,各地要因地制宜,合理选用。既可以利用村庄、河流、土丘、树林等
我国设施园艺业发展迅速，总面积位居世界第一，但是绝大多数设施都为简易型，对环境可控程度比较低，保温、增温能力差，寒冷的季节寒害频频发生;温室与塑料大棚的平均透光率只能达到5
人们经常提到现代科学理论中的“新三论”,其中之一就是耗散结构论。1969年,比利时著名科学家普里高津提出了关于耗散结构的假说。1977年,这一学说荣膺诺贝尔奖金,从而获得
Ovarian cancer is a common and lethal cancer affecting women globally.Berbamine is a natural compound from the plant Berberis amurensis,which is used in Chinese
本试验从果实品质、采后贮藏期间果实黑心病发生情况以及果心部分营养元素含量水平三个方面研究了采前施氮和灌水处理对提前10天采收和正常采收鸭梨果实常温贮藏和冷藏条件下
近期来,学校常反映投影器聚焦不清,认为是投影器质量有问题。经过多次的检查,我们发现多数投影器的质量没有间题,聚焦不清主要是由于使用不当而造成的。现将我了解到的投影