【摘 要】
：
Characterizing the three-dimensional (3D) morphological alterations of microvessels under both normal and seizure conditions is crucial for a better understanding of epilepsy.However,conventional imaging techniques cannot detect microvessels on micron/sub
【机 构】
：
Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China;School o
论文部分内容阅读
Characterizing the three-dimensional (3D) morphological alterations of microvessels under both normal and seizure conditions is crucial for a better understanding of epilepsy.However,conventional imaging techniques cannot detect microvessels on micron/sub-micron scales without angiography.In this study,synchrotron radiation (SR)-based X-ray in-line phase-contrast imaging (ILPCI) and quantitative 3D characterization were used to acquire high-resolution,high-contrast images of rat brain tissue under both normal and seizure conditions.The number of blood microvessels was markedly increased on days 1 and 14,but decreased on day 60 after seizures.The surface area,diameter distribution,mean tortuosity,and number of bifurcations and network segments also showed similar trends.These pathological changes were confirmed by histological tests.Thus,SR-based ILPCI provides systematic and detailed views of cerebrovascular anatomy at the micron level without using contrast-enhancing agents.This holds considerable promise for better diagnosis and understanding of the pathogenesis and development of epilepsy.
其他文献
Regenerating functional new neurons in the adult mammalian central nervous system hasbeen proven to be very challenging due to the inability of neurons to divide and repopulate themselves after neuronal loss. Glial cells, on the other hand, can divide and
Electroacupuncture (EA) has been shown to reduce blood lipid level and improve cerebral ischemia in rats with hyperlipemia complicated by cerebral ischemia. However, there are few studies on the results and mechanism of the effect of EA in reducing blood
Nogo-A is considered one of the most important inhibitors of myelin-associated axonal regeneration in the central nervous system. It is mainly expressed by oligodendrocytes. Although previous studies have found regulatory roles for Nogo-A in neurite outgr
The blood-spinal cord barrier plays a vital role in recovery after spinal cord injury. The neurovascular unit concept emphasizes the relationship between nerves and vessels in the brain, while the effect of the blood-spinal cord barrier on the neurovascul
The adult human brain represents about 2％ of the body weight,yet consumes about 20％ of the body\'s total energy.A key constituent in meeting this high energy demand is a complex cerebral vascular system.A detailed knowledge of this system is important f
We previously found that argon exerts its neuroprotective effect in part by inhibition of the toll-like receptors (TLR) 2 and 4. The downstream transcription factors signal transducer and activator of transcription 3 (STAT3) and nuclear factor kappa B (NF
Patients with diabetes mellitus have a higher risk of developing Parkinson\'s disease (PD).However,the molecular links between PD and diabetes remain unclear.In this study,we investigated the roles of thioredoxininteracting protein (TXNIP) in Parkin/PIN
Many blood biomarkers are reportedly helpful for predicting post-stroke cognitive impairment (PSCI), but no biomarkers are widely used in clinical practice. The purpose of this study was to investigate the association between the plasma immunoproteasome a
Spinal cord injury (SCI) is a serious traumatic event to the central nervous system. Studies show that long non-coding RNAs (lncRNAs)play an important role in regulating the inflammatory response in the acute stage of SCI. Here, we investigated a new lncR
Alzheimer\'s disease (AD) is the most common type of dementia, but it is very difficult to diagnose with certainty, so many AD studies have attempted to find early and relevantdiagnostic markers. Regulated upon activation, normal T cell expressed and se