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背景:原发性进行性失语综合征是一种少见类型的痴呆综合征,国内报道较少。目的:报告1例发生在中国的以非流利型失语为主要临床表现的原发性进行性失语综合征患者。设计:以患者为研究对象,观察性研究,病例分析。单位:一所大学医院和一所军区总医院的神经科。对象:患者,男性,64岁,右利手,于2002-04哈尔滨医科大学第一临床医学院入院。方法:患者进行了神经心理学检查、头部组织成像检查(CT和MRI)和功能成像检查犤单光子发射计算机断层脑显像(SPECT)犦。主要观察指标:①神经心理学检查结果。②影像学检查结果。结果:神经心理学检查显示为非流利型失语,以命名不能为首发症状。CT和MRI示“左侧半球颞叶萎缩,外侧裂周围区域增宽”,SPECT示“左侧颞叶、额叶及部分顶叶血流灌注降低”。结论:患者的临床表现、神经心理学和神经影像学检查结果支持原发性进行性失语综合征的诊断。
Background: Primary progressive aphasia syndrome is a rare type of dementia syndrome with few reports in China. OBJECTIVE: To report one case of primary progressive aphasia syndrome in China with non-fluent aphasia as the main clinical manifestation. Design: The patient as the research object, observational studies, case analysis. Unit: a university hospital and a military general hospital neurology. PARTICIPANTS: Patient, male, 64 years old, right hand, admitted to First Clinical College of Harbin Medical University in 2002-04. METHODS: Patients underwent neuropsychological tests, head and neck tissue imaging (CT and MRI), and functional imaging examinations 犤 single photon emission computed tomography (SPECT) 犦. MAIN OUTCOME MEASURES: ① Neuropsychological test results. ② imaging examination results. Results: Neuropsychological tests showed non-fluent aphasia, which could not be named as the first symptom. CT and MRI showed “the left hemisphere temporal lobe atrophy, widening outside the lateral fissure”, SPECT shows “left temporal lobe, frontal lobe and part of the parietal lobe perfusion decreased.” Conclusions: The patient’s clinical presentation, neuropsychological and neuroimaging findings support the diagnosis of idiopathic progressive aphasia syndrome.