妊娠急性脂肪肝(AFLP)是妊娠后期特有的疾病,1940年Sheehan 肯定了其组织学改变。早期报告本病预后凶险,近年来由于早期诊断并采取了积极的综合治疗措施,包括尽早终止妊娠及注意对轻型病例的识别等,预后明显改善。笔者从临床所见,结合新近文献对本病作一系统介绍,以供参考。一、发生率:直至1980年仍认为本病罕见,英文文献不足百例,估计发生率为1/100万次分娩,此后又有数十例报告,其中以1985年Rolfes 所报告的35例临床病理研究为迄今最大系列,并认为本病在妊娠后期肝功能异常者中更为常见,某些病例被误诊,轻型病例被遗漏。Kaplan(1985)报告本病的发生率为1/13328次分娩。国内自北京传染病医院、北京医专病 Acute fatty liver of pregnancy (AFLP) is a peculiar disease of late pregnancy, Sheehan affirmed its histological changes in 1940. Early reports of the prognosis of this disease dangerous, in recent years due to early diagnosis and take a comprehensive positive treatment measures, including early termination of pregnancy and attention to the identification of light cases, the prognosis was significantly improved. I see from the clinic, combined with recent literature on the disease for a systematic introduction for reference. First, the incidence: Until 1980, the disease is still considered rare, the English literature less than 100 cases, the estimated incidence of 1 million births, and then there are dozens of reports, of which Rolfes in 1985 reported 35 cases of clinical Pathology is by far the largest series and is considered more common in patients with abnormal liver function during late pregnancy, with some cases misdiagnosed and light cases omitted. Kaplan (1985) reported a disease incidence of 1/13328 deliveries. Domestic since Beijing Infectious Diseases Hospital, Beijing medical disease