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目的 :探讨排石颗粒配合盐酸坦洛新对电子输尿管软镜治疗大于2.0 cm肾结石的临床疗效。方法 :将2015年3月—2017年3月江苏大学附属医院90例应用输尿管软镜治疗直径大于2.0 cm的肾结石患者随机分为实验组和对照组,每组各45例。实验组配合中药排石颗粒及盐酸坦洛新缓释片,对照组仅配合盐酸坦洛新。服药后每周复查1次,疗程4周或至排石干净。分别于第2周、第4周进行疗效判定。观察指标为结石清除率、肾绞痛发生概率、结石排出时间以及膀胱过度活动症(OABSS)评分。结果 :(1)实验组结石清除率为97.8%,对照组清除率为86.7%,差异具有统计学意义(P<0.05);(2)治疗组结石排出时间为(5.6±1.67)d,对照组排出时间为(12.7±2.63)d,差异具备统计学意义(P<0.05);(3)实验组肾绞痛发生率为8.9%,对照组发生率为24.4%,差异具备统计学意义(P<0.05);(4)实验组OABSS评分为(5.3±1.19)分,对照组OABSS评分为(11.2±2.67)分,差异具备统计学意义(P<0.05)。结论 :排石颗粒配合盐酸坦洛新对电子输尿管软镜治疗大于2.0 cm结石患者具有结石清除率高、肾绞痛发生概率小、结石排出时间短以及并发症少的治疗优势。
Objective: To investigate the clinical efficacy of Paishi granules combined with tamsulosin hydrochloride on the treatment of renal calculi larger than 2.0 cm by electronic ureteroscope. Methods: From March 2015 to March 2017, 90 patients with nephrolithotomy who were treated with ureteroscopy in the Affiliated Hospital of Jiangsu University who were more than 2.0 cm in diameter were randomly divided into experimental group and control group, 45 cases in each group. Experimental group with traditional Chinese medicine Paishi granules and tamsulosin hydrochloride sustained-release tablets, the control group only with tamsulosin hydrochloride. After taking a weekly review 1, treatment for 4 weeks or to row of stone clean. Respectively in the first 2 weeks, 4 weeks to determine efficacy. Observations were stone clearance, incidence of renal colic, stone discharge time and overactive bladder (OABSS) score. Results: (1) The stone clearance rate was 97.8% in the experimental group and 86.7% in the control group, the difference was statistically significant (P <0.05); (2) The treatment group was (5.6 ± 1.67) (12.7 ± 2.63) d, the difference was statistically significant (P <0.05); (3) The incidence of renal colic in the experimental group was 8.9% and that in the control group was 24.4%, the difference was statistically significant ( P <0.05). (4) The score of OABSS in the experimental group was (5.3 ± 1.19) points and that in the control group was (11.2 ± 2.67) points, the difference was statistically significant (P <0.05). CONCLUSIONS: Pai Pai Granules combined with tamsulosin hydrochloride in treatment of patients with more than 2.0 cm calculus by electronic ureteroscopy has the advantages of high stone clearance rate, small incidence of renal colic, shorter stone discharge time and less complications.