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目的:建立一种新的无创乙型肝炎病毒（hepatitis B virus，HBV）相关肝纤维化诊断模型。方法:回顾性分析我院332例行肝组织活检的慢性乙型病毒性肝炎患者，根据纤维化分期，分为轻度肝纤维化组（S<2）以及中重度肝纤维化组（S≥2）。检测患者肝纤维化血清学指标以及FIB-4指数，根据ROC曲线评价FIB-4与肝纤维化指标联合诊断肝纤维化的特异性及敏感度。结果:重度肝纤维化组患者FIB-4、血清PCⅢ及ⅣC水平均较轻度肝纤维化组高（n p<0.01），FIB-4、血清Ⅲ型前胶原（typeⅢ procdlagen，PCⅢ）及Ⅳ型胶原（type Ⅳ collagen，ⅣC）三者联合ROC曲线下面积为0.782，诊断中重度肝纤维化的灵敏度为71.5%，特异性为89.8%。n 结论:FIB-4与血清PCⅢ、ⅣC联合诊断HBV相关S2期以上肝纤维化分期具有较好的评估价值。联合FIB-4和血清PCⅢ、ⅣC可作为评估肝纤维化的一种无创检测方法。“,”Objective:To establish a new noninvasive diagnosis model for HBV associated liver fibrosis.Methods:The data of 332 patients with chronic hepatitis B who received liver biopsy in our hospital were analyzed retrospectively. Based on liver histopathological results, the patients were divided into two groups: mild fibrosis group (S<2) and medium to severe group (S≥2). The serum markers of liver fibrosis and fibrosis-4 (FIB-4) score were tested and the diagnosis sensitivity and specificity of FIB-4 combined with markers of liver fibrosis were assessed by the ROC curve.Results:FIB-4 score, serum type III procollagen (PCIII) and type IV collagen (IVC) in the medium to severe group were statistically higher than those in the mild group (n P<0.01). The area under curve (AUC) of ROC by FIB-4 score combined with serum PCIII and IVC was 0.782. The sensitivity of this combined assessment in the medium to severe fibrosis cases was 71.5% with the specificity of 89.8%.n Conclusions:FIB-4 score combined with serum PCIII and IVC showed diagnostic value in assessing the HBV associated fibrosis at stage 2 and above. The model of FIB-4 combined with serum PCIII and IVC could be a promising noninvasive method to assess liver fibrosis.