人被患狂犬病动物咬伤后有30—35％发生狂犬病,这种病一旦发病甚难救治,几无幸存者。现在由于狂犬疫苗的大量生产,及时应用,发病率已降至0.2—0.33％。我省延边地区两年内接受疫苗注射1266人中,发生狂犬病者仅3人,而未注疫苗123人中发生狂犬病竞多达18人,故狂犬疫苗在予防上是必要的。 可是,有少数接受疫苗注射者可能是由于对疫苗中的羊脑组织发生变态反应,1—2周后产生发热、头痛、呕吐、肢体麻木、昏迷、瘫痪、尿便障碍等类似脊髓炎、脑炎、脑膜炎等神经系统并发症,重者也有死亡或终身残废的危险。我校神经内科自1965—1974年间收容81例这样的病人,其中4例虽经积极抢救,仍归死亡。本文对此进行了临床分析,介绍了临床特点,病理所见,讨论了发病原理及治疗方法。 从本文统计数字看,由于疫苗发放数大量增加,本症病人也逐年增多,如何予防本症的问题日益突出。本文81例中有10例是家犬(非狂犬)咬伤,有3例是杀被狂犬咬伤的猪时手碰破,有2例只是被狗咬破棉裤,根本未伤及皮肉,而均因滥用疫苗造成不应有的后果。我们介绍这些情况提请基层防疫机构的重视,加强有关疫苗注射的宣传教育。从临床上看早期诊断,早期治疗,可收到较好效果,并可减少残废的发生。 People suffering from rabies animal bites 30-35% rabies, the disease is very difficult to treat the disease, few survivors. Now because of rabies vaccine mass production, timely application, the incidence has dropped to 0.2-0.33%. Among the 1266 people who received vaccine in Yanbian within two years of our province, only 3 people were rabies, while 18 rabies patients were not allowed to compete in 123 people. Therefore rabies vaccine is necessary for prevention. However, a small number of those receiving vaccine may be due to allergic reactions to the sheep’s brain tissue in the vaccine, fever, headache, vomiting, numbness, coma, paralysis, urinary problems and other similar myelitis after 1-2 weeks Inflammation, meningitis and other nervous system complications, severe cases also have the risk of death or permanent disability. Neurology in our school from 1965 to 1974, accommodating 81 cases of such patients, of which 4 cases despite the active rescue, still go to death. This article conducted a clinical analysis, introduced the clinical features, pathology, discussed the pathogenesis and treatment. Statistics from this article, due to a substantial increase in the number of vaccines issued, the disease also increased year by year, how to prevent the disease has become increasingly prominent. Of the 81 cases, 10 were bitten by domestic dogs (non-rabid dogs), 3 were hand-beaten by pigs bitten by rabid dogs, and 2 were bitten by dogs and did not hurt the flesh. Undesirable consequences have been caused by the abuse of the vaccine. We introduce these situations to draw the attention of the grass-roots epidemic prevention agencies, to strengthen the publicity and education on vaccination. Clinically, early diagnosis, early treatment, can receive better results, and can reduce the incidence of disability.