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本文采用抗淋巴细胞亚群的单克隆抗体和间接免疫荧光法,检测了9例宫颈癌患者外周血淋巴细胞亚群.测定结果:与良性病变对照组相比,宫颈癌组成熟 T 细胞数(T_3),辅助性 T 细胞数(T_4)减少,其相对百分比显著下降.抑制/杀伤性 T 细胞(T_8)增多,其相对百分比显著上升.T_4/T_8比值显著低于对照组.提示宫颈癌患者细胞免疫功能低下.机体免疫缺陷有利于癌肿发展,可能是癌肿持续生长的重要因素之一.外周血淋巴细胞亚群的测定有助于了解宫颈癌与机体免疫改变之间的关系.
In this study, anti-lymphocyte subsets of monoclonal antibodies and indirect immunofluorescence assay in 9 cases of cervical cancer patients with peripheral blood lymphocyte subsets.Results: Compared with the benign lesion control group, the number of mature T cells in cervical cancer group ( T_3 and T_4, the relative percentage decreased significantly.The relative percentage of T_8 / T_8 increased significantly.The ratio of T_4 / T_8 was significantly lower than that of the control group.It suggested that cervical cancer patients Immunocompromised cells are good for the development of cancer and may be one of the important factors for the continuous growth of cancer.Determination of peripheral blood lymphocyte subsets may help to understand the relationship between cervical cancer and immune changes.