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目的观察安胃降逆饮对胃功能的影响 ,分析其镇吐作用机制。方法采用大鼠离体胃条法测定胃条张力 ,小鼠酚红排空试验法测定胃排空量和 0 .1mol/LNaOH滴定法测定胃酸含量。结果安胃降逆饮对大鼠胃肌的基础张力和乙酰胆碱引起的痉挛性收缩有明显抑制作用 (P <0 .0 1) ;对小鼠胃排空 ,大鼠胃液量 ,胃液酸度及总酸度无明显影响 (P >0 .0 5 )。结论安胃降逆饮的镇吐作用至少部分是通过抑制胃肠平滑肌蠕动而发挥作用的。
Objective To observe the effect of Anwei Jiangniyin on gastric function and analyze its antiemetic mechanism. Methods Gastric strip tension was measured by the rat stomach strip method. The gastric emptying volume was determined by the phenol red emptying test method and the gastric acid content was measured by a 0.1 mol/L NaOH titration method. [Results] Anwei Jiangniyin had obvious inhibitory effect on the basal strain of gastric muscle and spastic contraction caused by acetylcholine (P < 0.01); gastric emptying of rats, gastric juice volume, acidity and total gastric juice in mice There was no significant effect of acidity (P > 0.05). Conclusion The antiemetic effects of Anwei Jiangniyin play at least partly by inhibiting the motility of gastrointestinal smooth muscle.