当StevenPaget于1889年发表“种子与土壤”理论时,产生了癌细胞血行转移的概念。一个多世纪后,随着分子工具的应用,新的临床研究发现已经能解释之前无法解释的现象,例如:在受体移植器官中易发生癌变;转移灶的所有癌细胞均是已知原发性肿瘤的“子孙”和此后转移灶的“原祖”。Cr When StevenPaget published the theory of “seed and soil” in 1889, the concept of metastasis of cancer cells was generated. More than a century later, with the use of molecular tools, new clinical studies have found that unexplained phenomena have been explained previously, such as carcinogenesis in recipient-transplanted organs; all cancerous cells in metastases are known primary “Offspring” of sex tumors and the “original progenitor” of metastases afterwards. Cr