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本文采用转蓝法测定了国内5个厂家的头孢氨苄片的溶出度,实验数据用单指数分布函数拟合,求得溶出速率常数ki值,并对ki值进行方差分析。结果表明:不同厂家的ki值有非常显著的差异(p<0.01)。
In this paper, the dissolution rate of cefalexin tablets in five domestic manufacturers was determined by the turn-around blue method. The experimental data were fitted with a single exponential distribution function to obtain the ki value of the dissolution rate constant, and the variance analysis of the ki value. The results show that: ki values from different manufacturers have very significant differences (p <0.01).