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目的 研究汉防已甲素对急性缺血性肾衰的保护作用。方法 术前 ３ｄ开始每天 １次及术前 １ｈ ｉｇ汉防已甲素 ２０ｍｇ／ｋｇ、４０ ｍｇ／ｋｇ。然后制作大鼠肾脏缺血再灌注致急性缺血性肾衰模型，测定肾组织中 ＭＤＡ、ＳＯＤ、Ｎａ＋，Ｋ＋－ＡＴＰ酶和Ｃａ２＋－ＡＴＰ酶含量及切片观察肾脏形态。结果 缺血6０ｍｉｎ再灌注２０ｍｉｎ后肾组织中 ＭＤＡ明显升高，ＳＯＤ、Ｎａ＋、Ｋ＋－ＡＴＰ酶和 Ｃａ２＋－ＡＴＰ酶均显著降低。用药组 ＭＤＡ显著下降，ＳＯＤ和 ＡＴＰ酶均明显升高。病理结果提示再灌注组肾小管上皮明显变性，而用药组损害明显减轻。结论 汉防已甲素对急性缺血性肾衰有一定的保护作用。
Objective To study the protective effect of tetrandrine on acute ischemic renal failure. METHODS: We started ig and 20 mg/kg and 40 mg/kg twice daily for 1 h before surgery and 1 h before surgery. Then, the model of acute ischemic renal failure induced by renal ischemia-reperfusion in rats was established. The contents of MDA, SOD, Na+, K+-ATPase, and Ca2+-ATPase in kidney tissue were measured and the kidney morphology was observed by sectioning. RESULTS: After 60 min ischemia and 20 min reperfusion, MDA content in kidney tissue increased significantly, and SOD, Na+, K+-ATPase and Ca2+-ATPase significantly decreased. In the medication group, MDA significantly decreased, and SOD and ATPase increased significantly. Pathological results suggest that the renal tubular epithelium was significantly degenerated in the reperfusion group, while the damage in the medication group was significantly reduced. Conclusion Hancopene has a protective effect on acute ischemic renal failure.