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目的通过高危型HPV16/18感染状况分析,探讨HPV感染对宫颈病变早期筛查的价值。方法选择227例不同宫颈病变患者作为研究对象,以妇科健康体检者138例作为对照。应用聚合酶链反应(PCR)分析宫颈脱落细胞HPV16/18感染状况。结果宫颈炎患者93例,HPV16阳性6例,HPV18阳性4例,二者均阳性1例;宫颈上皮细胞内瘤变(包括CINⅠ、Ⅱ及Ⅲ级)患者98例,HPV16阳性24例,HPV18阳性10例,二者均阳性7例;宫颈癌患者36例,HPV16阳性15例,HPV18阳性5例,二者均阳性9例。宫颈上皮细胞内瘤变与宫颈癌患者中,HPV16感染较HPV18感染多见,HPV16/18阳性率随宫颈病变的严重程度增加而上升,差异有统计学意义(P<0.01)。三组不同宫颈病变患者的HPV16/18感染的年龄分布也存在差异,差异有统计学意义(P<0.01)。结论 HPV16和18感染阳性率与宫颈病变的严重程度密切相关,提示可通过HPV16和18感染的早期筛查,及时发现宫颈病变患者。
Objective To investigate the value of HPV infection in the early screening of cervical lesions by analyzing the status of high-risk HPV16 / 18 infection. Methods A total of 227 patients with different cervical lesions were selected as research objects, and 138 healthy gynecologists were used as controls. The HPV16 / 18 infection in cervical exfoliated cells was analyzed by polymerase chain reaction (PCR). Results There were 93 cases of cervicitis, HPV16 positive in 6 cases and HPV18 positive in 4 cases, both were positive in 1 case. 98 cases of cervical intraepithelial neoplasia (including CINⅠ, Ⅱ and Ⅲ), HPV16 positive in 24 cases, HPV18 positive 10 cases, both were positive in 7 cases; 36 cases of cervical cancer, HPV16-positive in 15 cases, HPV18-positive in 5 cases, both were positive in 9 cases. Cervical intraepithelial neoplasia and cervical cancer patients, HPV16 infection more than HPV18 infection, HPV16 / 18 positive rate increased with the severity of cervical lesions increased, the difference was statistically significant (P <0.01). There were also differences in the age distribution of HPV16 / 18 infection between three groups of patients with different cervical lesions, the difference was statistically significant (P <0.01). Conclusion The positive rates of HPV16 and HPV18 infection are closely related to the severity of cervical lesions, suggesting early detection of cervical lesions by HPV16 and 18 early screening.