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目的:观察益肾抗雄方联合二甲双胍治疗多囊卵巢综合征(PCOS)胰岛素抵抗的临床疗效。方法:将100例PCOS胰岛素抵抗患者随机分为2组各50例。治疗组应用益肾抗雄方联合二甲双胍治疗,对照组采用二甲双胍治疗,均治疗12周。比较治疗前后的生殖激素水平、空腹胰岛素、空腹血糖、胰岛素抵抗指数、血脂水平的变化。结果:治疗12周后,2组促黄体生成素/卵泡刺激素(LH/FSH)、睾酮(T)、血脂、空腹血糖、空腹胰岛素、胰岛素抵抗指数水平均有改善,治疗组优于对照组,差异均有显著性意义(P<0.05),尤其LH/FSH治疗组降低显著。结论:益肾抗雄方联合二甲双胍可改善PCOS患者的LH/FSH水平,降低T、改善胰岛素的敏感性,降低血胰岛素水平,疗效显著。
Objective: To observe the clinical efficacy of Yixian Kangxiong Fang combined with metformin in the treatment of insulin resistance in patients with polycystic ovary syndrome (PCOS). Methods: 100 cases of PCOS insulin resistance were randomly divided into two groups of 50 cases. The treatment group was treated with Yishen Kangxiong combined with metformin, while the control group was treated with metformin for 12 weeks. The levels of reproductive hormone, fasting insulin, fasting blood glucose, insulin resistance index and blood lipid level before and after treatment were compared. Results: After 12 weeks of treatment, the levels of LH / FSH, T, serum lipids, fasting blood glucose, fasting insulin and insulin resistance index were all improved in the two groups, and the treatment group was better than the control group , The differences were significant (P <0.05), especially LH / FSH treatment group decreased significantly. CONCLUSION: YISHANG ANXIANG FORMULA COMBINED WITH METformin can improve the level of LH / FSH in PCOS patients, reduce T, improve the sensitivity of insulin and lower the level of insulin.