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本研究旨在分析冠心Ⅱ号方中组分的变化对芍药苷药动学性质的影响。将大鼠随机分组后分别静脉注射芍药苷提取物(PPE)、灌胃给予PPE及三种不同组成的水煎液,HPLC法测定给药后不同时间血浆中芍药苷浓度,并用非线性混合效应模型(NONMEM)法对全部数据进行药动学模型拟合。吸收相中带有一级降解速率的二室口服吸收模型可以用于描述芍药苷的体内药动学特征,药动学参数CL1、V1、CL2、V2、Ka0及Ka1的群体拟合值分别为0.509L/h,0.104L,0.113L/h,0.123L,0.135h–1及0.0135h–1,模型对个体间差异进行了估计,并以给药剂型(DF)作为固定效应对参数Ka1、Ka0和V1进行了校正。群体药动学方法可以用于分析冠心Ⅱ号中组方变化对芍药苷体内吸收和分布产生的影响。
The purpose of this study was to analyze the influence of the changes in the components of Guanxin Ⅱ Prescription on the kinetic properties of paeoniflorin. The rats were randomly divided into three groups: paeoniflorin (PPE), PPE and three kinds of decoctions by intragastric administration. The concentrations of paeoniflorin in plasma at different time after administration were measured by HPLC, Model (NONMEM) method for all data fitting pharmacokinetic model. The two-compartment oral absorption model with first-order degradation rate in the absorption phase can be used to characterize the pharmacokinetics of paeoniflorin. The population fitting values of pharmacokinetic parameters CL1, V1, CL2, V2, Ka0 and Ka1 are 0.509 The differences between individuals were estimated using the model of DF (0.113L / h, 0.123L, 0.135h-1 and 0.0135h-1) as the fixed effect on the parameters Ka1, Ka0 And V1 were corrected. The population pharmacokinetic method can be used to analyze the influence of the change of prescription in Guanxin II on the absorption and distribution of paeoniflorin.