本文报告1例肺炎球菌脑膜炎婴儿,用大剂量青霉素 G 静脉给药治疗无效,并证明细菌对青霉素不敏感。患儿系女婴,33个月。于出生后10个月曾施行脾切除术,随后出现高丙种球蛋白血症、白细胞增多症和无功能的细胞增加。于20个月时曾突然发生嗜睡、呕吐、发热,并出现血管性衰竭。3个月前,由于血中培养到肺炎球菌,给予苄星青霉素600,000单位,每月注射1次。在末次注射的第4天后发生 This article reports a case of pneumococcal meningitis infants, intravenous bolus injection of penicillin G ineffective, and prove that the bacteria are not sensitive to penicillin. Pediatric baby girl, 33 months. Splenectomy was performed 10 months after birth, followed by hypergammaglobulinemia, leukocytosis and non-functional cell augmentation. Sudden onset of lethargy, vomiting, fever and vascular failure occurred at 20 months. Three months ago, penicillin was given 600,000 units due to pneumococcal culture in the blood and injected once a month. Occurs 4 days after the last injection