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国产氟康唑(广东太阳神集团荔城制药厂生产)为三唑类第三代抗真菌药物,具有抗菌谱广(尤其对念珠菌、隐球等),毒性低,较好的药代动力学特点。我科自1996年10月至1997年4月收治肺部白色念珠菌感染30例,用氟康唑治疗取得满意疗效。1 临床资料1.1一般资料:国产氟康唑组30例,男性21例,女性9例,年龄58～73岁,其中滥用皮质类固醇5年1例,抗肿瘤化疗例;对照组30例患者,男性24例,女性6例,年龄61～74岁,应用进口氟康唑(商品名:大扶康)抗真菌治疗,其中放疗2例,4例应用糖皮质激素。2组病例均并存有下列疾病:COPD、肺心病、呼吸衰竭、肺癌、糖尿病等,发生真菌感染前均应用2种或多种广谱抗生素,用药时间在10天以上。
Domestic fluconazole (Guangdong Apollo Group Licheng Pharmaceutical Factory production) for the triazole third-generation antifungal agents, with broad antibacterial spectrum (especially for candida, cryptosphere, etc.), low toxicity, better pharmacokinetics Features. Our department from October 1996 to April 1997 admitted to the lung of Candida albicans infection in 30 cases, with fluconazole treatment to obtain satisfactory results. 1 Clinical data 1.1 General information: Domestic fluconazole group of 30 patients, 21 males and 9 females, aged 58 to 73 years, of which 1 case of abuse of corticosteroids for 5 years, anti-tumor chemotherapy; control group of 30 patients, male 24 cases, 6 females, aged 61 to 74 years old, the application of imported fluconazole (brand name: Daifang Kang) antifungal therapy, including radiotherapy in 2 cases, 4 cases of glucocorticoid. Two groups of patients had the following diseases: COPD, pulmonary heart disease, respiratory failure, lung cancer, diabetes, fungal infection occurred before the application of two or more broad-spectrum antibiotics, medication time in 10 days.