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本试验采用叙利亚金黄地鼠胚胎Ｓｙｒｉａｎｈａｍｓｔｅｒｅｍｂｒｙｏ（ＳＨＥ）细胞的体外恶性转化方法，检测出Ｔｒｉｓ（２－ｍｅｔｈｙｌ－１－ａｚｉｒｉｄｉｎｙｌ）ｐｈｏｓｐｏｈｉｎｅｏｘｉｄｅ（ＭＡＰＯ）可诱导ＳＨＥ细胞形态学恶性转化。转化细胞嗜碱性强、核浆比例增大、排列方向紊乱、可交叉重叠生长。从转化集落分离的细胞生长旺盛、染色体数目异常、可被较低浓度的植物凝集素凝集、在半固体琼脂内非贴壁依赖生长、接种免疫抑制动物可长出肿瘤。上述结果表明：ＭＡＰＯ具有诱导ＳＨＥ细胞恶性转化的作用，预示它对人类有潜在的致癌危险性。
In this experiment, malignant transformation of Syrian hamster embryos (SHE) cells in Syrian golden hamster embryos was used to detect the malignant transformation of SHE cells induced by Tris (2-methyl-1-aziridinyl) phospohineoxide (MAPO). The transformed cells have strong basophilicity, increased proportion of nuclear plasma, disorganized direction, and can overlap and grow. Cells isolated from the transformed colonies are prosperous, abnormal in chromosome number, agglutinated by lower concentrations of phytohemagglutinin, non-adherently dependent growth in semi-solid agar, and immunosuppressed animals can develop tumors. The above results indicate that MAPO has the function of inducing malignant transformation of SHE cells, indicating that it has a potential carcinogenic risk to humans.