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目的:探讨胃炎康加维酶素对胃癌前病变胃黏膜癌基因蛋白表达的影响。方法:免疫组化法检测治疗前后胃黏膜Ha-ras、EGFR、c-erbB2的表达。结果:治疗后胃黏膜癌基因蛋白的表达明显下调,其中胃炎康加维酶素治疗组的效果明显好于单纯维酶素组(对照组),无论是阳性表达率,还是表达强度(光密度积分)都优于对照组。结论:胃炎康加维酶素可能是通过抑制胃黏膜癌基因蛋白的异常表达而发挥治疗胃癌前病变的作用。
Objective: To investigate the effect of ganycanconazole on the expression of oncogene protein in gastric precancerous lesions. Methods: Immunohistochemistry was used to detect the expression of Ha-ras, EGFR and c-erbB2 in gastric mucosa before and after treatment. Results: After treatment, the expression of oncogene protein in gastric mucosa was significantly down-regulated, the effect of which was better than that of pure verapamil group (control group), the positive rate of expression or the intensity of expression (optical density Points) are better than the control group. Conclusion: Gastric Kang Kang Wei Wei enzyme may play a role in the treatment of gastric precancerous lesions by inhibiting the abnormal expression of gastric mucosa oncogene protein.