论文部分内容阅读
目的探讨热休克蛋白70mRNA(HSP70mRNA)在胃癌发生中的意义。方法取胃癌44例,癌旁不典型增生20例,单纯不典型增生16例,浅表性胃炎20例。采用核酸原位杂交技术(ISH)检测HSP70mRNA表达状况。结果在胃癌、癌旁不典型增生和单纯不典型增生中HSP70mRNA的阳性率分别为61.36(27/44)、55.00%(11/20)和31.25%(5/16);在浅表性胃炎组阳性率为5.00%(1/20)。HSP70mRNA表达与癌细胞浸润深度和淋巴结转移无明显相关性。结论HSP70mRNA在胃癌形成早期有较高表达,检测HSP70mRNA可以作为胃癌早期诊断的指标。
Objective To investigate the significance of heat shock protein 70mRNA (HSP70mRNA) in gastric carcinogenesis. Methods Twenty-four cases of gastric cancer, 20 cases of atypical hyperplasia, 16 cases of atypical hyperplasia and 20 cases of superficial gastritis. HSP70 mRNA expression was detected by in situ hybridization (ISH). Results The positive rates of HSP70 mRNA in gastric cancer, adjacent atypical hyperplasia and atypical hyperplasia were 61.36 (27/44), 55.00% (11/20) and 31.25% (5/16), respectively. In the group of superficial gastritis The positive rate was 5.00% (1/20). There was no significant correlation between the expression of HSP70mRNA and the depth of invasion and lymph node metastasis. Conclusion HSP70 mRNA is highly expressed in the early stage of gastric cancer. Detecting HSP70 mRNA can be used as an indicator of early diagnosis of gastric cancer.