论文部分内容阅读
目的探讨不同程度肝病患者血清甲状腺激素水平的变化及其意义。方法应用放射免疫法分别检测114例慢性肝炎、130例肝硬化、96例重型肝炎、120例健康体检者的血清甲状腺激素水平(T3、T4、FT3、FT4、rT3、TSH),抗甲状腺过氧化物酶抗体(抗TPO)、抗甲状腺球蛋白抗体(抗TG)的含量变化。结果肝病患者较正常人血清甲状腺素水平(T3、T4、FT3、FT4)显著降低,而抗TPO、抗TG、rT3含量显著升高,差异有统计学意义;随着肝功能受损程度的加重,血清甲状腺素水平(T3、T4、FT3、FT4)降低程度差异有统计学意义。结论肝病患者血清甲状腺激素水平的检测对评估肝功能、判断病程及预测预后有一定的临床意义。
Objective To investigate the changes of serum thyroid hormones in patients with different degrees of liver disease and its significance. Methods Serum thyroid hormone levels (T3, T4, FT3, FT4, rT3, TSH) in 114 patients with chronic hepatitis, 130 patients with cirrhosis, 96 patients with severe hepatitis and 120 healthy controls were detected by radioimmunoassay. Antibody (anti-TPO), anti-thyroglobulin antibody (anti-TG) content changes. Results Serum levels of thyroxine (T3, T4, FT3, FT4) were significantly lower in patients with liver disease than those in normal controls, while the levels of anti-TPO, anti-TG and rT3 were significantly increased with a significant difference , Serum thyroxine levels (T3, T4, FT3, FT4) decreased significantly. Conclusion The detection of serum thyroid hormone in patients with liver disease has some clinical significance in assessing the liver function, judging the course of the disease and predicting the prognosis.