Objective: To explore angiopoietins (Ang-1, Ang-2)/Tie-2 expression and angiogenesis in stomach carcinomas. Methods: RT-PCR and immunohistochemistry were used to detect angiopoietins/Tie- 2 mRNA and protein expression in stom- ach carcinomas and their adjacent normal mucosa. Microvessel density (MVD) was counted according to CD34 immunohisto- chemical staining. Results: There was positive expression of Angiopoietins/Tie-2 mRNA and protein in stomach carcinomas and their paired adjacent normal mucosa. It was found that correlation between Ang-1 protein, Tie-2 mRNA expression and MVD was negative (r=–0.440, r=–0.267; P<0.05), while the correlation between Ang-2 mRNA and its protein, Ang-2/Ang-1 protein ratio and MVD was positive (r=0.319, r=729, r=739; P<0.05). Moreover, MVD in groups with Ang-2 mRNA T/N ratio over 1.2 (the ratio of Ang-2 mRNA in stomach carcinoma to its adjacent normal mucosa) was higher than those with the ratio under 1.2. Conclusion: It was suggested that Ang-1 and Ang-2 antagonizes in the angiogenesis and the angiogenesis in tumor ultimately depended on Ang-2/Ang-1 ratio, once the expression of Ang-2 is higher than Ang-1 in some degree, the angiogenesis in tumors was promoted, otherwise oppositely. In other words, Ang-2 plays dominant role in the action of angiogenesis in tumors. Objective: To explore angiopoietins (Ang-1, Ang-2) / Tie-2 expression and angiogenesis in stomach carcinomas. Methods: RT-PCR and immunohistochemistry were used to detect angiopoietins / Tie- 2 mRNA and protein expression in stom- ach carcinomas Results: There was positive expression of Angiopoietins / Tie-2 mRNA and protein in stomach carcinomas and their paired adjacent normal mucosa. It was found that The correlation between Ang-1 protein, Tie-2 mRNA expression and MVD was negative (r = -0.440, r = -0.267; 1 protein ratio and MVD was positive (r = 0.319, r = 729, r = 739; P <0.05) stomach carcinoma to its adjacent normal mucosa) was higher than those with the ratio under 1.2. Conclusion: It was suggested that Ang-1 an d Ang-2 antagonizes in the angiogenesis and the angiogenesis in tumor ultimately depended on Ang-2 / Ang-1 ratio, once the expression of Ang-2 is higher than Ang-1 in some degree, the angiogenesis in tumors was promoted, otherwise oppositely. In other words, Ang-2 plays a dominant role in the action of angiogenesis in tumors.