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大多数癫癎患者的发作通过药物治疗可以得到很好的控制,但大约25%的癫癎患者发作难以控制,癫癎的多药耐药机理仍然不明。已经发现了一些危险因子,认为可能与多药耐药有关,其中最热点的是多药耐药基因表达的蛋白,即P糖蛋白(P-glycoprotein,P-gp)。最近有报道认为 P-gp 表达主要存在于癫癎病灶中,而临近的正常组织并没有检测到P-gp 表达增高,这说明 P-gp 的高表达最初可能是损伤的结果,而发作和损伤是一对恶性循环的关系,互为因果,最终两者共同导致 P-gp 的高表达。在癫痫动物模型中也发现惊厥性脑损伤区 P-gp 的高表达。此外,大量的研究已证实未成熟脑对惊厥性脑损伤的耐受能力远较成年脑组织强,由此我们推论:在保持同样发作持续时间的情况下,P-gp 的表
Most episodes of epilepsy can be well controlled by medical treatment, but seizures are difficult to control in about 25% of epileptic patients and the mechanisms of multidrug resistance in epilepsy remain unknown. A number of risk factors have been identified that may be associated with multidrug resistance. The hottest of these are the multidrug resistance gene-encoded proteins, P-glycoprotein (P-gp). Recently, it has been reported that the expression of P-gp mainly exists in epileptic lesions, while the adjacent normal tissue does not detect the increased expression of P-gp, which indicates that the high expression of P-gp may be the result of injury initially, and the onset and injury Is a vicious circle of relations, each causality, the two eventually lead to the high expression of P-gp. In epilepsy animal model also found that high expression of P-gp in concussion brain injury area. In addition, a large body of research has demonstrated that immature brains are much more tolerant of convulsive brain injury than adult brains, and we conclude that while maintaining the same duration of onset, the P-gp table