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通过对25例急性非淋巴细胞白血病(ANLL)骨髓中特异染色体的分析,除发现ANLL中常见的染色体异常t(9;22)4例,t(8;21)5例,t(15;17)2例del(16)(q22)2例外,还发现了ANLL—Ms中新的t(10;12)易位核型,另外,对3例慢粒急变染色体核型进行了分析,提出了ABL—BCR融合基因以外的原癌基因活化可能是慢粒急变的重要原因之一。通过对特异染色体患者愈后的分析,发现不同的染色体异常与患者的愈后密切相关,且染色体的改变与疾病的变化是一致的,其结果对于研究白血病的发现机理,临床诊断,判断愈后,都具有重要意义。
By analyzing the specific chromosomes in bone marrow of 25 patients with acute non-lymphocytic leukemia (ANLL), except for the common chromosome abnormality t(9;22) found in ANLL in 4 cases, t(8;21) in 5 cases, and t(15;17). Two cases of del(16)(q22)2 were exceptions, and a new t(10;12) translocation karyotype in ANLL-Ms was also found. In addition, three cases of acute karyotypes of CRM were analyzed and proposed. Activation of proto-oncogenes other than the ABL-BCR fusion gene may be one of the important causes of CRM. Through the analysis of patients with specific chromosomes, it was found that different chromosomal abnormalities are closely related to the patient’s later development, and the chromosome changes are consistent with changes in the disease. The results are useful for studying the discovery mechanism of leukemia, clinical diagnosis, and judgment , are of great significance.