论文部分内容阅读
目的探讨广西柳州地区地中海贫血筛查中异常血红蛋白Hb Q-Thailand的检测情况。方法回顾统计我院2016年4月至2016年3月共20 167例地贫筛查结果,以高效液相色谱HPLC法在4.60-4.70min检测到异常血红蛋白峰为指征筛出阳性病例。结果在20 167例地贫筛查结果中检出Hb Q-Thailand共21例,人群携带率0.078%;HPLC筛查阳性病例追踪到有进行地贫基因检测的17例,其中有-α4.2/αα有14例,-α4.2/-α4.2有1例,--SEA/-α4.2有2例;两例Hb Q-Thailand合并H病患者Hb A含量极低,而Hb Q-Thailand分别为63%和73.5%,说明其具有一定载氧代偿功能。结论 Hb Q-Thailand是柳州地区常见的一种异常血红蛋白,在地贫筛查中发现Hb Q-Thailand峰应引起重视,需对该人群进行遗传指导。
Objective To investigate the detection of abnormal hemoglobin Hb Q-Thailand in thalassemia screening in Liuzhou, Guangxi. Methods The data of 20 167 cases of thalassemia from April 2016 to March 2016 in our hospital were retrospectively analyzed. The positive cases were identified as the indication of abnormal hemoglobin peak by HPLC at 4.60-4.70 minutes. Results Twenty-one cases of Hb Q-Thailand were detected in 20 167 thalassemia screening samples and the population carrying rate was 0.078%. In the positive cases of HPLC screening, 17 cases were detected with thalassemia gene, including -α4.2 / αα in 14 cases, α4.2 / -α4.2 in 1 case, - SEA / -α4.2 in 2 cases; two cases of Hb Q-Thailand with H disease Hb A content is extremely low, and Hb Q -Thailand were 63% and 73.5%, indicating that it has a certain oxygen load compensatory function. Conclusions Hb Q-Thailand is a common abnormal hemoglobin in Liuzhou area. It should be noted that the peak of Hb Q-Thailand should be paid attention in the screening of thalassemia, and the population should be genetically guided.