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目的∶用微核及Ａｍｅｓ＇试验研究氢醌的遗传毒性。方法∶昆明种小鼠３０只，雌雄各半，随机分成６组，给予氢醌灌胃染毒，二次染毒法，剂量为８０ｍｇ／ｋｇ，５０ｍｇ／ｋｇ和３３ｍｇ／ｋｇ观察骨髓嗜多染红细胞微核发生率。用鼠伤寒沙门氏菌突变株ＴＡ９７，ＴＡ９８，ＴＡ１００，ＴＡ１０２作Ａｍｅｓ＇试验。结果∶氢醌染毒剂量与微核发生率呈剂量－反应关系。结论∶在加或不加Ｓ９活化系统条件下，各剂量组未能引起各菌株的回变菌落数增加。
Objective: To study the genotoxicity of hydroquinone with micronucleus test and Ames’ test. Methods: Thirty Kunming mice were divided into 6 groups randomly. The mice were randomly divided into 6 groups. The mice were orally administered with hydroquinone and the second dose was 80 mg / kg, 50 mg / kg and 33 mg / kg respectively. The incidence of erythrocyte micronucleus. Salmonella typhimurium mutants TA97, TA98, TA100, TA102 were used as Ames’ test. Results: The dosage of hydroquinone dose-response relationship with the incidence of micronuclei. CONCLUSIONS: Each dose group failed to cause an increase in the number of colonies returned by each strain with or without the S9 activation system.