肺毛细血管内皮细胞呈连续性,总面积约70m~2,不但增大了血气交换面积,而且也增加了血液与体内最大内皮细胞表面的接触。正是这种广泛接触,构成了肺主要非呼吸功能之一——对通过肺循环的血内底物进行代谢,此功能称为肺的代谢功能或药代动力学功能。虽然已研究的底物多数是内源性物质,而外源性、异生性及药物性底物较少,但是肺对药物的药代动力学肯定与内源性底物的药代动力学是完全不同的。 Pulmonary capillary endothelial cells in a continuous, total area of ​​about 70m ~ 2, not only increased blood gas exchange area, but also increased the blood and the body’s largest endothelial cell surface contact. It is this extensive contact that constitutes one of the major non-respiratory functions of the lungs - metabolism of blood substrates through the pulmonary circulation, a function referred to as the metabolic or pharmacodynamic function of the lungs. Although most of the studied substrates are endogenous, with fewer exogenous, heterogenic and drug substrates, the pharmacokinetics of lung-to-drug affirmation and the pharmacokinetics of endogenous substrates are Totally different.