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肾移植成功后,排斥和机会性感染即是构成威胁的主要问题,但移植后高血压常是影响病人长期生活质量的危险因素。在使用环孢素以前,许多中心报告移植后高血压的发病率至少为50%;1990年Broyer和Gordjani等人报告,目前的发病率更高,且在长期随访中不下降。移植病人在庆幸长期的移植肾功能改善的同时,心血管病的发病率也增加。移植后高血压的原因尚不十分清楚,目前认为与排斥、免疫抑制剂作用、移植肾动脉狭窄、病人原位肾脏疾病、移植肾复发性或再发性肾小球肾炎有关。
After the success of renal transplantation, rejection and opportunistic infections are the main issues posing a threat, but post-transplant hypertension is often a risk factor that affects the long-term quality of life of patients. Before using cyclosporine, many centers reported an incidence of post-transplant hypertension of at least 50%; in 1990, Broyer and Gordjani et al. Reported that the current morbidity is higher and does not decline during long-term follow-up. Transplantation patients are fortunate to have long-term improvements in renal graft function, while the incidence of cardiovascular disease also increases. The cause of post-transplant hypertension is not well understood and is currently believed to be associated with rejection, immunosuppressive agents, renal artery stenosis, patient’s kidney disease in situ, and recurrent or recurrent glomerulonephritis of the kidney.