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我们以蛛网膜下腔出血(SAH)患者为研究对象,采用实验组即反复腰穿放脑脊液加鞘内注射地塞米松与对照组单纯常规疗法进行对比研究,观测脑脊液(CSF)中脂质过氧化物(LPO)及超氧化物化酶(SOD)的变化。结果显示:反复腰穿放脑脊液加鞘内注射地塞米松有显著降低 CSF 中 LPO(P<0.01)的作用,减轻 CSF 中 SOD(P>0.01)下降水平,保护 SOD 活性,降低 SAH 患者脑血管痉挛(CVS)发生率,减轻自由基链反应对细胞膜性结构的损害,从而尽快缓解患者临床症状,减少后遗症。
We take patients with subarachnoid hemorrhage (SAH) as the object of study, the experimental group that repeated lumbar puncture and intrathecal dexamethasone intrathecal injection of conventional therapy compared with the control group to observe the cerebrospinal fluid (CSF) Oxide (LPO) and superoxide dismutase (SOD) changes. Repeated lumbar puncture and intrathecal injection of dexamethasone significantly reduced LPO (P <0.01), decreased the level of SOD (P> 0.01) in CSF, protected the activity of SOD and decreased the levels of cerebrovascular Spasm (CVS) incidence, reduce the free radical chain reaction damage to the cell membrane structure, so as to ease the clinical symptoms of patients and reduce sequelae.