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新生儿早发败血症目前仍是导致足月儿和早产儿围产期死亡及发生远期并发症的主要原因之一。国外新生儿早发败血症最常见的致病菌是B族溶血性链球菌(GBS或无乳链球菌)[1]。美国和加拿大均制定了对GBS定植孕妇产时预防性抗生素治疗的策略[1-3],因此美国GBS所致新生儿早发败血症下降了70%。我国孕妇GBS带菌率为8%～15%,低于国外,可能与未同时阴道、直肠取材、未使用GBS选择性肉汤增菌而直接接种平皿有关[4]。本文参照美国疾控中心和加拿大儿科学会有关指南,就如何评估和治疗新生儿早发败血症作一介绍。重点是通过循证依据回答以下问题:当新生儿有早
Premature septicemia is still one of the major causes of perinatal death and long-term complications in term infants and premature infants. Foreign Neonatal Premature Septicemia is the most common pathogens B hemolytic streptococcus (GBS or Streptococcus agalactiae) [1]. Both the United States and Canada have established strategies for giving birth-induced prophylactic antibiotics to GBS colonies [1-3] and therefore a 70% reduction in neonatal premature sepsis caused by GBS in the United States. China’s pregnant women GBS carrier rate of 8% to 15%, lower than abroad, may not be the same time vaginal, rectal drawing, not using GBS selective broth enrichment and inoculation Petri dishes [4]. This article refers to the CDC and the Canadian Pediatric Society guidelines for how to assess and treat neonatal sepsis made an introduction. The key is to answer the following questions by evidence base: When the newborn has early