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目的:探讨高血压病患者动态血压参数与左心室舒张功能的相关性。方法:入选原发性高血压患者137例,询问病史、体检并采用超声心动图测收缩末期左、右心房内径、左心室舒张末期内径(LVEDD)、左心室射血分数(LVEF)。左心室舒张功能测定用二尖瓣舒张早期血流峰值速度/舒张晚期血流峰值速度(E/A)值,以评价左室舒张功能。根据E/A值的大小将原发性高血压患者分为两组,E/A≥1组视为左心室舒张功能正常组(n=54例),E/A<1为左心室舒张功能不全组(n=83例)。患者均行24 h动态血压及血生化检测。结果:(1)左心室舒张功能不全组的24 h平均收缩压(24h SBP)、LVEDD明显高于功能正常组,差异有统计学意义(P<0.05)。(2)偏相关性分析显示左室舒张功能与LVEDD、24h SBP呈显著正相关(r值分别为0.70,0.40,P<0.01)。结论:高血压病患者动态血压参数与左心室舒张功能相关。
Objective: To investigate the relationship between ambulatory blood pressure parameters and left ventricular diastolic function in patients with essential hypertension. Methods: A total of 137 patients with essential hypertension were enrolled in this study. Their medical history, physical examination and left ventricular end diastolic diameter, left ventricular end-diastolic dimension (LVEDD) and left ventricular ejection fraction (LVEF) were measured by echocardiography. Left ventricular diastolic function was measured by mitral early diastolic blood flow peak velocity / late diastolic blood flow peak velocity (E / A) values to assess left ventricular diastolic function. According to the size of E / A, patients with essential hypertension were divided into two groups. E / A≥1 group was regarded as normal left ventricular diastolic function group (n = 54), E / A <1 was left ventricular diastolic function Incomplete group (n = 83). Patients underwent 24 h ambulatory blood pressure and blood biochemical tests. Results: (1) The 24 h mean systolic blood pressure (24h SBP) and LVEDD in left ventricular diastolic dysfunction group were significantly higher than those in normal control group (P <0.05). (2) Partial correlation analysis showed that left ventricular diastolic function was positively correlated with LVEDD and 24h SBP (r = 0.70,0.40, P <0.01 respectively). Conclusion: The parameters of ambulatory blood pressure in hypertensive patients are related to left ventricular diastolic function.