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目的探讨大剂量外源性ＰＳ对家兔盐酸吸入性肺损伤的治疗作用。方法健康家兔２０只，气管内注入盐酸复制盐酸吸入肺损伤模型，分为２组：Ａ组（ｎ＝１０）为ＰＳ治疗组，气管内注入３７℃ＰＳ１００ｍｇ／ｋｇ；Ｂ组：（ｎ＝１０）为治疗对照组，气管内注入同等体积的生理盐水，观察ＰＳ对动脉血气和肺顺应性的影响。另设Ｃ组（ｎ＝８），在Ａ、Ｂ组动物模型复制及治疗相应时间气管内注入同等体积的生理盐水作为ＰＳ疗效的对照。结果Ａ组ＰＳ治疗后各时间点ＰａＯ２高于Ｂ组（Ｐ＜０．０５），但多数时间点仍低于Ｃ组（Ｐ＜０．０５）；Ａ组各时间ＰａＣＯ２均低于Ｂ组（Ｐ＜０．０１），治疗早期高于Ｃ组（Ｐ＜０．０５）；Ａ组动脉血ｐＨ值均低于Ｂ组，但Ｐ＞０．０５，与Ｃ组相比无差异（Ｐ＞０．０５）；Ａ组肺动、静态顺应性均优于Ｂ组（Ｐ＜０．０５），但仍低于Ｃ组（Ｐ＜０．０１）。结论大剂量猪肺表面活性物质可以明显地提高ＰａＯ２，降低ＰａＣＯ２，并且阻止动脉血ｐＨ的进一步下降，改善肺动、静态顺应性，对家兔盐酸吸入肺损伤具有治疗作用，为临床胃液误吸性肺损伤的治疗提供了一种新方法
Objective To investigate the therapeutic effect of high-dose exogenous PS on inhaled lung injury induced by hydrochloric acid in rabbits. Methods Twenty rabbits were randomly divided into two groups: group A (n = 10) was treated with PS and endotracheal intratracheal instillation of PS100mg / kg at 37 ℃; group B (n = 10) For the control group, the same volume of saline was injected into the trachea to observe the effect of PS on arterial blood gas and lung compliance. Another group C (n = 8) was injected intratracheally with the same volume of physiological saline as the control of PS efficacy in the animal model of group A and B at the corresponding time. Results PaO2 in group A at each time point was higher than that in group B (P <0.05), but most of the time points were still lower than those in group C (P <0.05); PaCO2 in group A at each time was lower than that in group B P <0.01). The arterial blood pH in group A was lower than that in group B, but P> 0.05. There was no difference between group A and group C (P> 0.05). The pulmonary compliance and static compliance in group A were better than those in group B (P <0.05), but still lower than those in group C (P <0.01). Conclusions High-dose lung surfactant can significantly increase PaO2, decrease PaCO2, prevent further drop of arterial pH, improve pulmonary compliance and static compliance, and have therapeutic effect on rabbit lung injury induced by hydrochloric acid inhalation. The treatment of lung injury provides a new method