近十余年来随着有机硅化学的迅速发展,硅烷化试剂的应用也日益广泛。利用硅烷化试剂在定向合成有机化合物时,具有一定的区域专一性(regiospecificity)和立体选择性(stereoselectivity),在反应过程中通常光学活性不受影响,手征性不变。另一方面,硅烷化试剂还可用作某些功能基的保护剂。目前,这类试剂无论在药物制备或是反应机理的研究等方面,都占有重要地位。硅烷化试剂的反应能力,和硅原子的性质有关。 In recent ten years, with the rapid development of silicone chemistry, the application of silanization reagents is also increasingly widespread. The use of silanization reagents in the directional synthesis of organic compounds, has a certain regiospecific registries and stereoselectivity (stereoselectivity), the reaction is usually not affected by the optical activity, chirality unchanged. Silanization reagents, on the other hand, can also be used as protective agents for certain functional groups. At present, these reagents occupy an important position both in the preparation of drugs and in the research of reaction mechanism. The reactivity of the silanization reagent depends on the nature of the silicon atom.