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辛伐他汀(Simvastatin)是一种新型的高效降血脂药,由于能阻断胆固醇的生物合成,单用或与胆酸螯合剂或烟酸等联用,对高胆固醇血症、冠心病(CHD)等有明显的疗效。国外以北欧辛伐他汀生存研究组的4S(Scandinavian Simvastatin Survival Study)研究为代表,对辛伐他汀的药理作用及临床应用已有着长期广泛的研究,并逐步应用到临床实践中,国内对辛伐他汀的研究也已逐步开始成为方兴未艾之势。
Simvastatin is a new type of highly effective lipid-lowering drug that blocks hypercholesterolemia, coronary heart disease (CHD) due to its ability to block the biosynthesis of cholesterol, alone or in combination with bile acid sequestrants or niacin ) And other obvious effect. In the overseas, the research of 4S (Scandinavian Simvastatin Survival Study) of simvastatin survival group in North Europe is the representative, which has long and extensive research on the pharmacological effect and clinical application of Simvastatin. It is gradually applied to clinical practice, The study of statins has gradually begun to become the ascendant trend.