啮齿动物模型只能表现出人类糖尿病肾病的早期特征,限制了对于新治疗方法的探讨。高血压是人类发生糖尿病肾病的前提条件之一,因此,在啮齿动物模型中罕见高血压可部分解释它们不易发生肾脏病变的原因。研究人员利用Cyp1a1mRen2转基因大鼠进行研究,这些大鼠的肾素Ⅱ基因由细胞色素P4501A1启动子驱动。用低剂量的吲哚3甲醇喂养该转基因大鼠可诱发中度高血压。结果显示在无高血压情况下,研究者利用链脲 Rodent models can only show the early features of human diabetic nephropathy, limiting the discussion of new therapeutic approaches. Hypertension is one of the prerequisites for developing diabetic nephropathy in humans, so that rare high blood pressure in rodent models may partly explain why they are less susceptible to kidney disease. The researchers used Cyp1a1Ren2 transgenic rats to study that the renin II gene in these rats is driven by the cytochrome P4501A1 promoter. Moderate hypertension was induced by feeding the transgenic rat with low doses of indole 3 methanol. The results show that in the absence of hypertension, the researchers use streptozotocin