β-内酰胺类抗生素(青霉素G)自40年代初应用临床以来,由于其高效、低毒,成为临床治疗感染性疾病的强有力武器,但由于长期广泛的应用,使多种细菌对β-内酰胺类抗生素产生了耐药性,而限制了其使用范围。人们通过研究发现,β-内酰胺酶(β-lase)是大多数致病菌对青霉素类和头孢菌素类等β-内酰胺抗生素产生耐药性的主要原因,因此酶能使β-内酰胺环水解开环而失 Since the clinical application of β-lactam antibiotics (penicillin G) since the early 40’s, due to its high efficiency, low toxicity, become a powerful weapon for the clinical treatment of infectious diseases, but due to long-term widespread application of a variety of bacteria on β- Lactam antibiotics have caused resistance, which limits the scope of its use. It has been found through research that β-lactamase is the major cause of resistance of most pathogenic bacteria to β-lactam antibiotics such as penicillins and cephalosporins. Therefore, β-lactamase can make β- Amide ring ring open and lost