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目的探讨百忧解治疗大面积烧伤伴抑郁患者的临床价值。方法将我院烧伤科于2013年7月2015年2月期间126例大面积烧伤伴抑郁患者平均分成观察组和对照组,对照组采用常规烧伤治疗,观察组在此基础上加用百忧解治疗,对比两组患者治疗前后的汉密尔顿抑郁量表(HAMD)评分并检测血清IL-6、TNF-α水平及血小板计数。结果治疗30 d后,观察组的HAMD评分明显低于对照组(P<0.01),创面愈合时间明显短于对照组(P<0.01),血清IL-6、TNF-α水平显著低于对照组(P<0.01),血小板计数显著高于对照组(P<0.01)。结论百忧解能有效抑制大面积烧伤患者的抑郁情绪,改善生理功能状态,具有重要的临床应用价值。
Objective To explore the clinical value of Prozac in the treatment of patients with extensive burn and depression. Methods Burn patients in our hospital from July 2013 to February 2015 were divided into observation group and control group with 126 cases of extensive burn with depression. The control group was treated with conventional burn treatment. The observation group was treated with Prozac The Hamilton Depression Rating Scale (HAMD) scores before and after treatment were compared and the levels of IL-6, TNF-α and platelet counts were measured. Results After 30 days of treatment, the HAMD score of the observation group was significantly lower than that of the control group (P <0.01), the wound healing time was significantly shorter than that of the control group (P <0.01), and the levels of serum IL-6 and TNF-α were significantly lower than those of the control group (P <0.01), and the platelet count was significantly higher than that of the control group (P <0.01). Conclusions Prozac can effectively suppress depression and improve physiological function in patients with extensive burn, which has important clinical value.