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目的 探讨肝硬化患者呼气中CO2 回收率和能量消耗的变化情况。方法 以13 C -碳酸氢钠 (NaH13 CO3 )为示踪剂 ,采用首剂量结合静脉恒速滴注法及气体同位素比值质谱技术 ,分别对 11例正常人和 14例肝硬化患者呼气中13 CO2 丰度进行测定 ,计算13 CO2 回收率和能量消耗。结果 正常人和肝硬化患者呼气中13 CO2 回收率 ,分别为 ( 80 7± 0 2 6) %和 ( 78 3± 0 84) % ,有显著性差异 ( P <0 0 5 ) ;根据CO2 产生率计算静止状态下能量消耗 ,分别为 ( 3 0 2± 2 4)Kcal·kg-1·d-1和 ( 2 8 4± 3 5 )Kcal·kg-1·d-1,无显著性差异 (P >0 0 5 )。结论 所测定结果可作为制订肝硬化病人营养治疗方案提供理论依据。
Objective To investigate the changes of CO2 recovery and energy expenditure in patients with cirrhosis. Methods 13 C - sodium bicarbonate (NaH13 CO3) was used as tracer and the first dose combined with intravenous infusion and gas isotope ratio mass spectrometry were used to detect the levels of serum lipids in 11 normal subjects and 14 patients with cirrhosis CO2 abundance was measured and 13 CO2 recovery and energy consumption were calculated. Results The recovery rates of 13 CO2 in exhaled air were (80 7 ± 0 2 6)% and (78 3 ± 0 84)% in normal and cirrhosis patients, respectively, with significant difference (P 0 05) The rate of energy expenditure at rest was calculated as (3 0 2 ± 2 4) Kcal · kg -1 · d -1 and (2 8 4 ± 3 5) Kcal · kg -1 · d -1, respectively, with no significant difference Difference (P> 0.05). Conclusion The results can be used as a theoretical basis for the development of nutritional therapy for patients with cirrhosis.