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目的:分析早产儿呼吸窘迫综合征(RDS)的危险因素,并探讨产前给予糖皮质激素的预防效果。方法:对150例RDS早产儿临床资料进行分析,选取相关因素进行单因素和多因素Logistic回归分析;并对出生的早产儿进行糖皮质激素预防治疗,分析早产儿RDS的相关危险因素和预防治疗方法。结果:出生窒息、宫内窘迫是引起早产儿RDS的高危因素,产前使用激素、胎膜早破是RDS的保护因素。采用糖皮质激素预防治疗后,观察组RDS发生率显著低于对照组,两组间差异有统计学意义(P<0.05)。结论:早产儿RDS高危的产妇,需要密切监测围产期的状况,预防脑部缺氧的发生;产前给予糖皮质激素预防治疗,可以显著降低新生儿RDS的发生率,提高早产儿的存活率。
Objective: To analyze the risk factors of respiratory distress syndrome (RDS) in preterm infants and to explore the preventive effect of prenatal glucocorticoid administration. Methods: The clinical data of 150 cases of premature infants with RDS were analyzed, the relevant factors were selected for univariate and multivariate Logistic regression analysis; and the glucocorticoid prophylaxis of premature infants was analyzed. The related risk factors and prevention and treatment of RDS method. Results: Asphyxia at birth and intrauterine distress were the risk factors of RDS in premature infants. Prenatal steroid use and premature rupture of membranes were the protective factors of RDS. After glucocorticoid treatment, the incidence of RDS in the observation group was significantly lower than that in the control group, with significant difference between the two groups (P <0.05). Conclusion: Preterm infants with high risk of RDS need to closely monitor the status of perinatal and prevent brain hypoxia. Prenatal glucocorticoid therapy can significantly reduce the incidence of RDS and improve the survival of premature infants rate.